Pharmacological action – antibacterial, antiprotozoal.
Pharmachologic effect
Pharmacological action – antibacterial, antiprotozoal.
Pharmacokinetics
Quickly and completely absorbed. T1 / 2 – 8-10 hours, binding to plasma proteins does not exceed 10-20%. Easily penetrates into tissues (lungs, kidneys, liver, skin, bile, cerebrospinal fluid, saliva, seminal fluid, vaginal secretion), into mother’s milk, overcomes the placental barrier. It is excreted by 40-70% (about 20% in unchanged form) through the kidneys.
Indications
Amoebiasis, urogenital trichomoniasis, nonspecific vaginitis, giardiasis (intestinal and hepatic), surgical infections caused by anaerobes.
Contraindications
Hypersensitivity.
Use during pregnancy and lactation
During pregnancy, it is prescribed with caution; during lactation, breastfeeding is stopped.
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