Pharmacological action – H1-antihistamine, antiallergic, antipruritic.
Pharmacodynamics
Non-sedating long-acting antihistamine. It is the primary active metabolite of loratadine. Suppresses the release of histamine from mast cells. Inhibits the cascade of allergic inflammation reactions, incl. release of pro-inflammatory cytokines, including IL-4, IL-6, IL-8, IL-13, release of adhesion molecules such as P-selectin. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, prevents the development of tissue edema, spasm of smooth muscles.
The drug does not affect the central nervous system, does not cause drowsiness (the use of desloratadine at the recommended dose of 5 mg / day is not accompanied by an increase in the incidence of drowsiness compared with the placebo group) and does not affect the speed of psychomotor reactions. In clinical and pharmacological studies of the use of desloratadine at the recommended therapeutic dose, there was no prolongation of the QT interval.
The action of the drug Erius® begins within 30 minutes after ingestion and lasts for 24 hours.
Pharmacokinetics
Desloratadine is well absorbed from the gastrointestinal tract. It is determined in blood plasma 30 minutes after ingestion. Tmax – an average of 3 hours. Does not penetrate the BBB. Communication with plasma proteins is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 to 20 mg 1 time per day, clinically significant cumulation of the drug is not observed. Simultaneous ingestion of food or grapefruit juice does not affect the distribution of desloratadine when used at a dose of 7.5 mg 1 time per day. Desloratadine is not an inhibitor of CYP3A4 and CYP2D6, a substrate or an inhibitor of P-gp. It is extensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine combined with glucuronide. Only a small part of the oral dose is excreted by the kidneys (<2%) and through the intestines (<7%) unchanged. T1 / 2 on average 27 hours.
Indications
allergic rhinitis (elimination or relief of sneezing, nasal congestion, discharge of mucus from the nose, itching in the nose, itching of the palate, itching and redness of the eyes, watery eyes);
urticaria (reduction or elimination of skin itching, rash).
Payment and delivery:
https://pahrmacydiscount.com/delivery
Delivery AERIUS from Europe
Delivery AERIUS from the Czech Republic
Delivery AERIUS from Germany
Delivery AERIUS from Russia
Delivery AERIUS from France
Delivery AERIUS from Italy
Buy AERIUS in Europe
Buy AERIUS in the Czech Republic
Buy AERIUS in Germany
Buy AERIUS in Russia
Buy AERIUS in France
Buy AERIUS in Italy
Delivery of AERIUS in Moscow
Delivery of AERIUS in Kiev
Delivery of AERIUS in Minsk
Delivery of AERIUS in London
Delivery of AERIUS in St. Petersburg
Delivery of AERIUS in Kharkov
Delivery of AERIUS in Paris
Delivery of AERIUS in Madrid
Delivery of AERIUS in Munich
Delivery of AERIUS in Brussels
Delivery of AERIUS in Amsterdam
Delivery of AERIUS in Copenhagen
Order Form:
- The name of the medicine
- Dosage
- Brand
- Quantity
Send to e-mail doradorapharm@gmail.com
In search engines are looking for
Купить ЭРИУС 5 МГ, 50, Цена ЭРИУС 5 МГ, 50
Купити ЭРИУС 5 МГ, 50Ціна ЭРИУС 5 МГ, 50
Kupit ЭРИУС 5 МГ, 50Ceni ЭРИУС 5 МГ, 50
Buy AERIUS 5 MG, 50, Price AERIUS 5 MG, 50
Acheter AERIUS 5 MG, 50, Prix AERIUS 5 MG, 50
Para comprar AERIUS 5 MG, 50, Precio AERIUS 5 MG, 50
Zu kaufen AERIUS 5 MG, 50, Preis AERIUS 5 MG, 50
Kupić AERIUS 5 MG, 50, Cena AERIUS 5 MG, 50
Koupit AERIUS 5 MG, 50, Cena AERIUS 5 MG, 50
للشراء AERIUS 5 MG, 50, السعر AERIUS 5 MG, 50
Satın almak AERIUS 5 MG, 50, fiyat AERIUS 5 MG, 50
Comprare AERIUS 5 MG, 50, prezzo AERIUS 5 MG, 50
Sotib olish uchun AERIUS 5 MG, 50, Narxlari AERIUS 5 MG, 50
Για να αγοράσετε AERIUS 5 MG, 50, Τιμή AERIUS 5 MG, 50
შეძენა AERIUS 5 MG, 50, ფასი AERIUS 5 MG, 50
Satın almaq üçün AERIUS 5 MG, 50, Qiymət AERIUS 5 MG, 50
Para comprar AERIUS 5 MG, 50, Precio AERIUS 5 MG, 50
Comprar AERIUS 5 MG, 50, Preço AERIUS 5 MG, 50
Popular medicine from Czech Republic, to buy medicine from France, delivery of medicine from Germany, how to buy medicine from Czech Republic to America, how to buy medicine from France to England, Online Pharmacy from Germany, Internet Pharmacy from Czech Republic, International Pharmacy in Europe, Pharmacy from Europe, Medical cosmetics from France, Natural cosmetics from Europe or Canada, Vitamins from Europe or America, Nutritional supplements from Europe and Poland, Products from Czech Republic, to order medicine from Germany
Popular prescription drugs from the Czech Republic, to buy prescription drugs from France, delivery of prescription drugs from Germany, how to buy prescription drugs from the Czech Republic to America, how to buy prescription drugs from France to England, how to order prescription drugs from Europe, delivery of prescription drugs from Europe and across Euro