Indicated for adults and children for the treatment of edema associated with congestive heart failure, cirrhosis of the liver and renal failure, including nephrotic syndrome. LASIX is especially useful when a drug with a high diuretic potential is required.
Pharmacokinetics
When taken orally, bioavailability is 64%. Cmax increases with increasing dose, but the time to reach the maximum does not depend on the dose and varies widely depending on the patient’s condition. T1 / 2 – about 2 hours In plasma, 91–99% binds to protein, 2.4–4.1% is in a free state. Biotransformed mainly into glucuronide. It is excreted in the urine (after intravenous administration more than when taken orally).
Clinical pharmacology
The onset of the diuretic effect, when taken orally, is observed already within 1 hour, the maximum effect is after 1-2 hours, the duration is 6-8 hours. 2 h. When administered intravenously, it causes varicose veins, rapidly reduces preload, reduces pressure in the left ventricle and the pulmonary artery system, and reduces systemic pressure.
Indications for Lasix®
Edema syndrome of various origins (cardiac, hepatic, renal after the second month of pregnancy, intoxication), pulmonary and cerebral edema, arterial hypertension, forced diuresis, renal failure.
Contraindications
Hypersensitivity (including to other sulfone and sulfonamides), acute glomerulonephritis, renal failure with anuria, hepatic coma, impaired water-salt balance and acid base balance (hypokalemia, hyponatremia).
Application during pregnancy and lactation
When pregnant, it should be used according to strict indications and only for a short time. During treatment, breastfeeding should be suspended.
Side effects
Hypotension, arrhythmia, dry mouth, nausea, vomiting, diarrhea, pancreatitis, hypovolemia, dehydration, hypokalemia, hyponatremia, hypochloremia, metabolic alkalosis, hypocalcemia, hyperuricemia, dermatitis, hearing impairment, vision, paresthesia, dizziness, dizziness patients with prostate adenoma, hypercholesterolemia, hypertriglyceridemia, decreased glucose tolerance, acute pancreatitis, allergic reactions (rash, fever, vasculitis, interstitial nephritis); in premature babies – nephrocalcinosis.
Interaction
Increases the risk of developing intoxication with cardiac glycosides (against the background of glucocorticoids, the likelihood of hypokalemia), nephro- and ototoxic effects of aminoglycosides, cephalosporins, cisplatin; enhances the effect of curariform agents; increases the reabsorption of lithium in the renal tubules. NSAIDs reduce the diuretic effect.
Method of administration and dosage
Inside, it is usually prescribed on an empty stomach; IV is injected for at least 1-2 minutes. In mild edematous syndrome, the initial dose for adults is 20–80 mg when taken orally or 20–40 mg IV; in the case of persistent edema – the same or increasing by 20–40 mg (by 20 mg for parenteral administration), the dose can be re-administered no earlier than 6–8 hours (2 hours for parenteral administration) until a diuretic effect is obtained; this individually adjusted dosage can be applied 1 or 2 times a day. The greatest efficiency is achieved when the drug is taken 2-4 days a week. For children, the initial dosage is 2 mg / kg of body weight (for parenteral administration – 1 mg / kg), if the effect is unsatisfactory, it can be increased by 1-2 mg / kg (for parenteral administration – by 1 mg / kg), but not earlier than after 6-8 hours (for parenteral administration, this period is at least 2 hours). With arterial hypertension, the initial dosage for adults is 80 mg per day in 2 divided doses. With pulmonary edema, Lasix is administered intravenously at a dose of 40 mg, if necessary, after 20 minutes, the drug can be administered at a dose of 20 to 40 mg.
Precautions
A possible decrease in the reaction rate should be taken into account (it should be carefully prescribed when driving vehicles and servicing mechanisms).
Storage conditions of the drug Lasix®
In a dark place at a temperature not exceeding 30 ° C.
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